Integrating Functional Data to Prioritize Causal Variants in Statistical Fine-Mapping Studies
نویسندگان
چکیده
منابع مشابه
Integrating Functional Data to Prioritize Causal Variants in Statistical Fine-Mapping Studies
Standard statistical approaches for prioritization of variants for functional testing in fine-mapping studies either use marginal association statistics or estimate posterior probabilities for variants to be causal under simplifying assumptions. Here, we present a probabilistic framework that integrates association strength with functional genomic annotation data to improve accuracy in selectin...
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ژورنال
عنوان ژورنال: PLoS Genetics
سال: 2014
ISSN: 1553-7404
DOI: 10.1371/journal.pgen.1004722